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Evidence

Clinical significance

Also known as: clinical importance, clinically meaningful change

The practical importance of a result for health, function or the decisions patients face.

Source-checked educational compilation · Not independently clinically reviewed

What this means in a clinic conversation

A statistically detectable difference can still be too small to matter to a person. Interpretation should consider the size of change, uncertainty, harms and patient priorities.

A question to bring

Would the size of the reported benefit make a meaningful difference in daily life?

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Related and commonly confused terms

Use the term in context

Sources and editorial context

This definition was compiled from the sources below and has not received independent clinical review. It supports understanding and consultation preparation.

  1. Interpreting results and drawing conclusions · CochraneReference checked 2026-10-02
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